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Lehninger Principles of Biochemistry: Fourth edition

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Biosynthesis of Cholesterol, Steroids, and Isoprenoids Box 21–1 Mixed-Function Oxidases, Oxygenases, and Cytochrome P-450 The 8th edition has been fully revised for up-to-date content, as well as to effectively support student study. Written for students learning biochemistry for the first time, the authors have identified and noted fundamental biochemistry principles throughout the text. Content has been streamlined so the text is focused on what is most important and useful to modern students and for future reference! Biochemistry: Concepts and Connections (2nd Edition) By Dean R. Appling, Spencer J. Anthony-Cahill and Christopher K. Mathews Tools for understanding are provided including ‘Key Conventions’ and ‘Special Themes’ (Metabolic Integration, Obesity, and Diabetes, Evolution) as well as ‘Medical Insights and Applications-Icons’ used throughout the book denote material of special medical interest and updated to reflect the most current content. New information on the initiation of replication and the dynamics at the replication fork, introducing AAA+ ATPases and their functions in replication and other aspects of DNA metabolism 26 RNA Metabolism

Where possible, figures have been simplified, and many figures now have step-by-step annotations, reducing caption length. The Structure of Proteins: Primary Structure Box 3–1 Methods: Absorption of Light by Molecules: The Lambert-Beer Law Box 3–2 Methods: Investigating Proteins with Mass Spectrometry Box 3–3 Medicine: Consensus Sequences and Sequence Logos

New medical box, introduces hemoglobin glycation and AGEs and their role in the pathology of advanced diabetes This edition provides a new learning path for students, through emphasis on the fundamental principles of biochemistry.

Case Studies’ introduce students to a biochemical mystery and allows them to determine what investigations will solve it. Accompanying assessments ensure that students have fully completed and understood the case study, showing that they have applied their knowledge of the concepts. Course and book-specific resources including adaptive quizzing to personalise the experience for students. New medical box on the use of protein kinase inhibitors in cancertherapy II BIOENERGETICS AND METABOLISM Interactive Metabolic Map allows students to navigate and zoom between overviews and detailed views of the most commonly taught metabolic pathways. Embedded Tours take students through the pathways step-by-step, helping them to both visualize concepts in isolation and understand how concepts are connected. By examining the pathways in this way, students are better equipped to understand the meaning of those connections. Assessment questions help students solidify their understanding and provide more structure to their learning. *Metabolic Pathways include: glycolysis, gluconeogenesis, the citric acid cycle, oxidative phosphorylation, the pentose phosphate pathway, fatty acid synthesis, the urea cycle, and β oxidation.Box 16–3 Citrate: A Symmetric Molecule That Reacts Asymmetrically Box 16–4 Citrate Synthase, Soda Pop, and the World Food Supply A detailed gradebook with insights for just-in-time teaching and reporting on student and full class achievement by learning objective. Expanded and integrated treatment of local signaling circuits, including AKAPs and signaling complexes that include protein kinase A, adenylyl cyclase, and phosphodiesterase, and localized puffs and waves of Ca2+

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